| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM143783 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Rat and Human Orexin 1 Receptor Radioligand Binding Studies |
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| Ki | 21.0±n/a nM |
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| Citation |  Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Substituted 2-azabicycles and their use as orexin receptor modulators US Patent US10183953 Publication Date 1/22/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
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| Type: | Protein |
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| Mol. Mass.: | 46817.55 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P56718 |
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| Residue: | 416 |
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| Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
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| BDBM143783 |
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| n/a |
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| Name | BDBM143783 |
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| Synonyms: | US10183953, Example 44 | US8969352, 44 | US9611277, Example 44 | US9845333, 44 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17F4N5O2 |
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| Mol. Mass. | 447.3856 |
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| SMILES | Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 |TLB:12:11:7.8:24,5:7:11.10:24| |
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| Structure | 
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