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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 4 | ||
| Ligand | BDBM100954 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Omnia Assay | ||
| IC50 | <100±n/a nM | ||
| Citation |  D Agostino, LA; Sjin, RT; Niu, D; McDonald, JJ; Zhu, Z; Liu, H; Mazdiyasni, H; Petter, RC; Singh, J; Barrague, M; Gross, A; Munson, M Heteroaryl compounds and uses thereof US Patent US10189794 Publication Date 1/29/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 4 | |||
| Name: | Fibroblast growth factor receptor 4 | ||
| Synonyms: | CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF | ||
| Type: | Protein | ||
| Mol. Mass.: | 87957.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P22455 | ||
| Residue: | 802 | ||
| Sequence: |
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| BDBM100954 | |||
| n/a | |||
| Name | BDBM100954 | ||
| Synonyms: | US10189794, Compound I-241 | US10618902, Compound I-241 | US10774052, Compound I-241 | US9695132, I-241 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H23Cl2N5O5 | ||
| Mol. Mass. | 520.365 | ||
| SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C)c1=O |r,wU:19.19,23.25,(9.29,-1.34,;9.29,.2,;7.95,.97,;7.95,2.51,;6.62,3.28,;6.62,4.82,;5.29,5.59,;5.29,2.51,;3.95,3.28,;5.29,.97,;6.62,.2,;6.62,-1.34,;3.95,.2,;2.62,.97,;1.28,.2,;-.05,.97,;-1.38,.2,;-1.38,-1.34,;-2.72,-2.11,;-4.05,-1.34,;-4.05,.2,;-5.51,.67,;-6.42,-.57,;-5.51,-1.82,;-5.91,-3.3,;-7.4,-3.7,;-8.49,-2.61,;-7.8,-5.19,;-9.29,-5.59,;-.05,-2.11,;1.28,-1.34,;2.62,-2.11,;2.62,-3.65,;3.95,-1.34,;5.29,-2.11,)| | ||
| Structure | 
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