| Reaction Details |
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 | Report a problem with these data |
| Target | Envelope glycoprotein gp160 |
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| Ligand | BDBM324110 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of HIV replication |
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| EC50 | 12.0±n/a nM |
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| Citation |  Eastman, KJ; Kadow, JF; Parcella, KE; Naidu, BN; Wang, T; Yin, Z; Zhang, Z Substituted pyridines as inhibitors of human immunodeficiency virus replication US Patent US10189816 Publication Date 1/29/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Envelope glycoprotein gp160 |
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| Name: | Envelope glycoprotein gp160 |
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| Synonyms: | ENV_HV1S1 | Env polyprotein | Glycoprotein 120 | Glycoprotein 41 | SU | Surface protein gp120 | TM | Transmembrane protein gp41 | env | gp120 | gp41 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 96162.42 |
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| Organism: | Human immunodeficiency virus type 1 group M subtype B (isolate SF162)(HIV-1) |
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| Description: | ChEMBL_107610 |
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| Residue: | 847 |
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| Sequence: | MRVKGIRKNYQHLWRGGTLLLGMLMICSAVEKLWVTVYYGVPVWKEATTTLFCASDAKAY
DTEVHNVWATHACVPTDPNPQEIVLENVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVK
LTPLCVTLHCTNLKNATNTKSSNWKEMDRGEIKNCSFKVTTSIRNKMQKEYALFYKLDVV
PIDNDNTSYKLINCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNDKKFNGSGPCTNV
STVQCTHGIRPVVSTQLLLNGSLAEEGVVIRSENFTDNAKTIIVQLKESVEINCTRPNNN
TRKSITIGPGRAFYATGDIIGDIRQAHCNISGEKWNNTLKQIVTKLQAQFGNKTIVFKQS
SGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNTIGPNNTNGTITLPCRIKQIINRWQEV
GKAMYAPPIRGQIRCSSNITGLLLTRDGGKEISNTTEIFRPGGGDMRDNWRSELYKYKVV
KIEPLGVAPTKAKRRVVQREKRAVTLGAMFLGFLGAAGSTMGARSLTLTVQARQLLSGIV
QQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGKLICTTAVP
WNASWSNKSLDQIWNNMTWMEWEREIDNYTNLIYTLIEESQNQQEKNEQELLELDKWASL
WNWFDISKWLWYIKIFIMIVGGLVGLRIVFTVLSIVNRVRQGYSPLSFQTRFPAPRGPDR
PEGIEEEGGERDRDRSSPLVHGLLALIWDDLRSLCLFSYHRLRDLILIAARIVELLGRRG
WEALKYWGNLLQYWIQELKNSAVSLFDAIAIAVAEGTDRIIEVAQRIGRAFLHIPRRIRQ
GFERALL
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| BDBM324110 |
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| n/a |
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| Name | BDBM324110 |
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| Synonyms: | US10189816, Compound 103 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H51N3O4 |
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| Mol. Mass. | 613.8292 |
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| SMILES | CCOc1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1 |r| |
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| Structure | 
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