Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 | ||
Ligand | BDBM324513 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | JAK Enzyme Assays | ||
Ki | 0.400±n/a nM | ||
Citation | Cheng, Y; Hua, R; Kellar, T; Li, W; Gibbons, P; Zak, ME Therapeutic compounds, compositions and methods of use thereof US Patent US10189836 Publication Date 1/29/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 | |||
Name: | Tyrosine-protein kinase JAK1 | ||
Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
Type: | Protein | ||
Mol. Mass.: | 133293.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458 | ||
Residue: | 1154 | ||
Sequence: |
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BDBM324513 | |||
n/a | |||
Name | BDBM324513 | ||
Synonyms: | 1-[4-(thietan-3- yl)piperazin-1-yl]-2-[4-[4 [[8-[8-[3- (trifluoromethyl)cyclo- butanecarbonyl]-3,8- diazabicyclo[3.2.1]octan- 3-yl]-[1,2,4]triazolo[1,5-a] pyridin-2- yl]amino]pyrazol-1- yl]ethanone | US10189836, Example 82 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H37F3N10O2S | ||
Mol. Mass. | 658.741 | ||
SMILES | FC(F)(F)[C@@H]1C[C@@H](C1)C(=O)N1C2CCC1CN(C2)c1cccn2nc(Nc3cnn(CC(=O)N4CCN(CC4)C4CSC4)c3)nc12 |r,wU:6.8,4.3,(12.15,-6.04,;10.81,-5.27,;10.04,-6.6,;11.58,-3.93,;9.48,-4.5,;9.08,-3.01,;7.59,-3.41,;7.99,-4.9,;6.26,-2.64,;4.93,-3.41,;6.26,-1.1,;4.93,-.33,;5.53,.52,;6.99,.52,;7.59,-.33,;7.59,1.21,;6.26,1.98,;4.93,1.21,;6.26,3.52,;7.59,4.29,;7.59,5.83,;6.25,6.6,;4.92,5.83,;3.46,6.3,;2.55,5.05,;1.01,5.05,;.24,3.72,;.87,2.31,;-.27,1.28,;-1.61,2.05,;-3.07,1.58,;-4.22,2.61,;-3.9,4.11,;-5.68,2.13,;-6.83,3.16,;-8.29,2.69,;-8.61,1.18,;-7.47,.15,;-6,.62,;-10.08,.7,;-11.45,1.4,;-12.15,.03,;-10.78,-.67,;-1.29,3.56,;3.46,3.81,;4.92,4.29,)| | ||
Structure |