Reaction Details |
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Target | Tumor necrosis factor |
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Ligand | BDBM324769 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TNF induced HEK-Blue assay |
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IC50 | <1000±n/a nM |
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Citation | Xiao, H; Dhar, MT; Duan, J; Jiang, B; Tebben, AJ Substituted tricyclic heterocyclic compounds US Patent US10189840 Publication Date 1/29/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Tumor necrosis factor |
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Name: | Tumor necrosis factor |
Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
Type: | Enzyme |
Mol. Mass.: | 25645.11 |
Organism: | Homo sapiens (Human) |
Description: | P01375 |
Residue: | 233 |
Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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BDBM324769 |
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n/a |
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Name | BDBM324769 |
Synonyms: | US10189840, Example 15 |
Type | Small organic molecule |
Emp. Form. | C25H22F3N3O2 |
Mol. Mass. | 453.4563 |
SMILES | CC(C)(O)c1ccc(cc1)-c1ccc2nc3C(F)CC(c4ccccc4OC(F)F)n3c2n1 |w:19.20,16.17| |
Structure |
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