| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK |
|---|
| Ligand | BDBM326173 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay |
|---|
| IC50 | 2.00±n/a nM |
|---|
| Citation |  Liu, J; Kim, RM; Kozlowski, J; Krikorian, AD; Anand, R Btk inhibitors US Patent US9637486 Publication Date 5/2/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase BTK |
|---|
| Name: | Tyrosine-protein kinase BTK |
|---|
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 76289.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q06187 |
|---|
| Residue: | 659 |
|---|
| Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
|
|
|
|---|
| BDBM326173 |
|---|
| n/a |
|---|
| Name | BDBM326173 |
|---|
| Synonyms: | 3-[(3R)-1-acetylpiperidin- 3-yl]-1-(4- phenoxyphenyl)-1H- pyrazolo[3,4-c]pyridin-7- amine | US9637486, Example 14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H25N5O2 |
|---|
| Mol. Mass. | 427.4983 |
|---|
| SMILES | CC(=O)N1CCC[C@H](C1)c1nn(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
