Reaction Details |
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Target | Tyrosine-protein kinase BTK |
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Ligand | BDBM326211 |
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Substrate/Competitor | n/a |
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Meas. Tech. | LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay |
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IC50 | 0.660±n/a nM |
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Citation | Liu, J; Kim, RM; Kozlowski, J; Krikorian, AD; Anand, R Btk inhibitors US Patent US9637486 Publication Date 5/2/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase BTK |
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Name: | Tyrosine-protein kinase BTK |
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
Type: | Enzyme |
Mol. Mass.: | 76289.95 |
Organism: | Homo sapiens (Human) |
Description: | Q06187 |
Residue: | 659 |
Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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BDBM326211 |
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n/a |
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Name | BDBM326211 |
Synonyms: | 3-[(3R)-1- acryloylpiperidin-3-yl]-1- (4-phenoxyphenyl)-1H- pyrazolo[3,4-c]pyridin-7- amine | US11739090, Compound 7A | US9637486, Example 23 |
Type | Small organic molecule |
Emp. Form. | C26H25N5O2 |
Mol. Mass. | 439.509 |
SMILES | Nc1nccc2c(nn(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C |
Structure |
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