Reaction Details |
| Report a problem with these data |
Target | Leukotriene A-4 hydrolase |
---|
Ligand | BDBM326947 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzyme Assay |
---|
IC50 | 0.100±n/a nM |
---|
Citation | Bylock, LA Benzodioxane inhibitors of leukotriene production for combination therapy US Patent US9662339 Publication Date 5/30/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Leukotriene A-4 hydrolase |
---|
Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
Type: | Hydrolase; metalloprotease |
Mol. Mass.: | 69280.41 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant LTA4H. |
Residue: | 611 |
Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
|
|
|
BDBM326947 |
---|
n/a |
---|
Name | BDBM326947 |
Synonyms: | 1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2-yl]benzyl}-2- methylpiperidine | US9662339, 68 |
Type | Small organic molecule |
Emp. Form. | C21H25NO2 |
Mol. Mass. | 323.4287 |
SMILES | CC1CCCCN1Cc1ccc(cc1)[C@H]1COc2ccccc2O1 |r| |
Structure |
|