Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM329008 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Caliper Assay |
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IC50 | 20.0±n/a nM |
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Citation | Collins, I; Matthews, TP; Mchardy, TF; Osborne, J; Lainchbury, M; Walton, MI; Garrett, MD 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile and therapeutic uses thereof US Patent US9663503 Publication Date 5/30/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM329008 |
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n/a |
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Name | BDBM329008 |
Synonyms: | 1137477-35-0 | US11787792, Compound Y-102 | US9663503, Compound Y-102 |
Type | Small organic molecule |
Emp. Form. | C22H22N8O2 |
Mol. Mass. | 430.4625 |
SMILES | O=C(Nc1ccccc1)c1cnc(Nc2cnc(cn2)C#N)cc1NCC1CNCCO1 |
Structure |
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