| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM196180 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Functional Activity (Agonism) on Human S1P1 Receptors (Method B) |
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| Temperature | 298.15±n/a K |
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| EC50 | 630±n/a nM |
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| Comments | extracted |
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| Citation |  Smid, P; Iwema Bakker, WI; Coolen, HK; Sliedregt, LA; van Dongen, MJ; den Hartog, JA; Hobson, A Fused heterocyclic derivatives as S1P modulators US Patent US9670220 Publication Date 6/6/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42836.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21453 |
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| Residue: | 382 |
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| Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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| BDBM196180 |
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| n/a |
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| Name | BDBM196180 |
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| Synonyms: | US9670220, 156 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23F3N2O4 |
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| Mol. Mass. | 460.4456 |
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| SMILES | CC(CN1CCc2oc(nc2C1)-c1ccc(OCc2ccc(cc2)C(F)(F)F)cc1)C(O)=O |
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| Structure | 
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