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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sphingosine 1-phosphate receptor 3 | ||
| Ligand | BDBM196263 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro Functional Activity (Agonism) on Human S1P3 Receptors | ||
| EC50 | >10000±n/a nM | ||
| Citation |  Smid, P; Iwema Bakker, WI; Coolen, HK; Sliedregt, LA; van Dongen, MJ; den Hartog, JA; Hobson, A Fused heterocyclic derivatives as S1P modulators US Patent US9670220 Publication Date 6/6/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sphingosine 1-phosphate receptor 3 | |||
| Name: | Sphingosine 1-phosphate receptor 3 | ||
| Synonyms: | C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 42278.13 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q99500 | ||
| Residue: | 378 | ||
| Sequence: |
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| BDBM196263 | |||
| n/a | |||
| Name | BDBM196263 | ||
| Synonyms: | US9670220, 277 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H22F2N2O4 | ||
| Mol. Mass. | 440.4393 | ||
| SMILES | OC(=O)[C@H]1CC(C1)N1CCc2oc(nc2C1)-c1ccc(OCc2ccc(F)c(F)c2)cc1 |r,wU:3.2,(10.37,-1.61,;9.12,-2.52,;7.72,-1.89,;9.28,-4.05,;8.81,-5.51,;7.28,-5.35,;7.75,-3.89,;5.94,-6.12,;5.94,-7.66,;4.61,-8.43,;3.28,-7.66,;1.81,-8.14,;.91,-6.89,;1.81,-5.65,;3.28,-6.12,;4.61,-5.35,;-.64,-6.89,;-1.41,-8.23,;-2.94,-8.23,;-3.72,-6.89,;-5.26,-6.89,;-6.03,-5.56,;-7.57,-5.56,;-8.34,-6.89,;-9.88,-6.89,;-10.65,-5.56,;-12.19,-5.56,;-9.88,-4.22,;-10.65,-2.89,;-8.34,-4.23,;-2.94,-5.56,;-1.41,-5.56,)| | ||
| Structure | 
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