| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Ligand | BDBM330388 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Cyp17 Assay |
|---|
| IC50 | 5.00±n/a nM |
|---|
| Citation |  Blass, BE; Abou-Gharbia, MA; Childers, WE; Iyer, P; Boruwa, J Cytochrome P450 inhibitors and their method of use US Patent US9725436 Publication Date 8/8/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Synonyms: | CP17A_BOVIN | CYP17 | CYP17A1 | Cytochrome P450 21 (CYP21) | Cytochrome P450-C17 (CYP17A1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57256.42 |
|---|
| Organism: | Bos taurus (Bovine) |
|---|
| Description: | P05185 |
|---|
| Residue: | 509 |
|---|
| Sequence: | MWLLLAVFLLTLAYLFWPKTKHSGAKYPRSLPSLPLVGSLPFLPRRGQQHKNFFKLQEKY
GPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKGIAFADHGAH
WQLHRKLALNAFALFKDGNLKLEKIINQEANVLCDFLATQHGEAIDLSEPLSLAVTNIIS
FICFNFSFKNEDPALKAIQNVNDGILEVLSKEVLLDIFPVLKIFPSKAMEKMKGCVQTRN
ELLNEILEKCQENFSSDSITNLLHILIQAKVNADNNNAGPDQDSKLLSNRHMLATIGDIF
GAGVETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPTISDRNRLVLLEATIREV
LRIRPVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEWQHPDLFMPERFLDP
TGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDDGKLPSLEGHA
SLVLQIKPFKVKIEVRQAWKEAQAEGSTP
|
|
|
|---|
| BDBM330388 |
|---|
| n/a |
|---|
| Name | BDBM330388 |
|---|
| Synonyms: | US9725436, Entry 7 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H26ClN3O2S |
|---|
| Mol. Mass. | 480.022 |
|---|
| SMILES | Clc1cc(\C=C\c2ccc(cc2)N2CCN(CC2)S(=O)(=O)C2CC2)cc(c1)-c1ccncc1 |
|---|
| Structure | 
|
|---|
Search and Browse
