| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Ligand | BDBM330392 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cyp17 Assay |
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| IC50 | 58.0±n/a nM |
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| Citation |  Blass, BE; Abou-Gharbia, MA; Childers, WE; Iyer, P; Boruwa, J Cytochrome P450 inhibitors and their method of use US Patent US9725436 Publication Date 8/8/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Synonyms: | CP17A_BOVIN | CYP17 | CYP17A1 | Cytochrome P450 21 (CYP21) | Cytochrome P450-C17 (CYP17A1) |
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| Type: | Protein |
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| Mol. Mass.: | 57256.42 |
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| Organism: | Bos taurus (Bovine) |
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| Description: | P05185 |
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| Residue: | 509 |
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| Sequence: | MWLLLAVFLLTLAYLFWPKTKHSGAKYPRSLPSLPLVGSLPFLPRRGQQHKNFFKLQEKY
GPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKGIAFADHGAH
WQLHRKLALNAFALFKDGNLKLEKIINQEANVLCDFLATQHGEAIDLSEPLSLAVTNIIS
FICFNFSFKNEDPALKAIQNVNDGILEVLSKEVLLDIFPVLKIFPSKAMEKMKGCVQTRN
ELLNEILEKCQENFSSDSITNLLHILIQAKVNADNNNAGPDQDSKLLSNRHMLATIGDIF
GAGVETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPTISDRNRLVLLEATIREV
LRIRPVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEWQHPDLFMPERFLDP
TGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDDGKLPSLEGHA
SLVLQIKPFKVKIEVRQAWKEAQAEGSTP
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| BDBM330392 |
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| n/a |
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| Name | BDBM330392 |
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| Synonyms: | US9725436, Entry 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25FN4O2S |
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| Mol. Mass. | 440.534 |
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| SMILES | CS(=O)(=O)N1CCN(CC1)c1ccc(\C=C\c2cc(F)cc(Cn3ccnc3)c2)cc1 |
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| Structure | 
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