| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ABL1 [Y253F] |
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| Ligand | BDBM332705 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Biochemical Assay |
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| Ki | 3.40±n/a nM |
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| Citation |  Soellner, MB; Phadke, S Inhibitors of BCR-ABL mutants and use thereof US Patent US10196378 Publication Date 2/5/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ABL1 [Y253F] |
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| Name: | Tyrosine-protein kinase ABL1 [Y253F] |
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| Synonyms: | ABL | ABL1 | ABL1_HUMAN | JTK7 | c-abl (Y253F) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 122881.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00519[Y253F] |
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| Residue: | 1130 |
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| Sequence: | MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSE
NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN
SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS
DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT
DITMKHKLGGGQFGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ
LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI
HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS
DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNP
SDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAE
HRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLF
SALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP
KPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSAS
CVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTV
TPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGS
ALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP
PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVL
PATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPE
RIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNK
FAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
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| BDBM332705 |
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| n/a |
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| Name | BDBM332705 |
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| Synonyms: | US10196378, Compound C08 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H27N7O2 |
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| Mol. Mass. | 529.5918 |
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| SMILES | CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccc4ncncc4c3)cc2)n(n1)-c1ccc2ncccc2c1 |
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| Structure | 
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