Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase B-raf |
---|
Ligand | BDBM333700 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Competition Binding Assay |
---|
Kd | <250±n/a nM |
---|
Citation | Abraham, S; Bhagwat, SS; Campbell, BT; Chao, Q; Faraoni, R; Holladay, MW; Lai, AG; Rowbottom, MW; Setti, E; Sprankle, KG RAF kinase modulator compounds and methods of use thereof US Patent US9730937 Publication Date 8/15/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase B-raf |
---|
Name: | Serine/threonine-protein kinase B-raf |
Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 84446.00 |
Organism: | Homo sapiens (Human) |
Description: | P15056 |
Residue: | 766 |
Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
|
|
|
BDBM333700 |
---|
n/a |
---|
Name | BDBM333700 |
Synonyms: | 1-(4- methoxy-3- (trifluoromethyl) phenyl)-3-(3-(6- methoxy-7-(2- morpholino- ethoxy) quinazolin- 4-yloxy)phenyl) urea | US9730937, Example 250 |
Type | Small organic molecule |
Emp. Form. | C30H30F3N5O6 |
Mol. Mass. | 613.5843 |
SMILES | COc1ccc(NC(=O)Nc2cccc(Oc3ncnc4cc(OCCN5CCOCC5)c(OC)cc34)c2)cc1C(F)(F)F |
Structure |
|