| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Ligand | BDBM333706 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Competition Binding Assay |
|---|
| Kd | <250±n/a nM |
|---|
| Citation |  Abraham, S; Bhagwat, SS; Campbell, BT; Chao, Q; Faraoni, R; Holladay, MW; Lai, AG; Rowbottom, MW; Setti, E; Sprankle, KG RAF kinase modulator compounds and methods of use thereof US Patent US9730937 Publication Date 8/15/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Name: | RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 73082.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P04049 |
|---|
| Residue: | 648 |
|---|
| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
|
|
|
|---|
| BDBM333706 |
|---|
| n/a |
|---|
| Name | BDBM333706 |
|---|
| Synonyms: | 1-(5-tert-butyl- isoxazol-3- yl)-3-(3-{7- [3-(1,1- dioxo-thio- morpholin- 4-yl)- propoxy]-6- methoxy- quinazolin-4- yloxy}- phenyl)-urea | US9730937, Example 256 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H36N6O7S |
|---|
| Mol. Mass. | 624.708 |
|---|
| SMILES | COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCCN1CCS(=O)(=O)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
