Reaction Details |
| Report a problem with these data |
Target | Carbonic anhydrase 4 |
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Ligand | BDBM13063 |
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Substrate/Competitor | BDBM11326 |
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Meas. Tech. | Carbonic Anhydrase Enzyme Inhibition Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 340±n/a nM |
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Citation | Weber, A; Casini, A; Heine, A; Kuhn, D; Supuran, CT; Scozzafava, A; Klebe, G Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition. J Med Chem47:550-7 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Carbonic anhydrase 4 |
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Name: | Carbonic anhydrase 4 |
Synonyms: | CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4 |
Type: | Enzyme |
Mol. Mass.: | 35152.74 |
Organism: | Bos taurus (bovine) |
Description: | Bovine isozyme, isolated from lung microsomes |
Residue: | 312 |
Sequence: | MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAK
TQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSR
AMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQ
PLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQK
PIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLA
PVLACLTVGFLR
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BDBM13063 |
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BDBM11326 |
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Name | BDBM13063 |
Synonyms: | 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonamide | Bextra | CHEMBL865 | VLX | Valdecoxib | cid_119607 |
Type | Small organic molecule |
Emp. Form. | C16H14N2O3S |
Mol. Mass. | 314.359 |
SMILES | Cc1onc(c1-c1ccc(cc1)S(N)(=O)=O)-c1ccccc1 |
Structure |
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