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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Potassium voltage-gated channel subfamily H member 2 | ||
| Ligand | BDBM315750 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Patch Clamp Assay | ||
| Ki | <10000±n/a nM | ||
| Citation |  Fuchss, T; Emde, U; Buchstaller, H; Mederski, W Arylquinazolines US Patent US9732094 Publication Date 8/15/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Potassium voltage-gated channel subfamily H member 2 | |||
| Name: | Potassium voltage-gated channel subfamily H member 2 | ||
| Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 126672.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q12809 | ||
| Residue: | 1159 | ||
| Sequence: |
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| BDBM315750 | |||
| n/a | |||
| Name | BDBM315750 | ||
| Synonyms: | US10172859, Example 171 | US10172859, Example 178 | US10172859, Example 179 | US11065253, Example 179 | US9732094, Example 179 | [3,4-Difluoro-5-(7- morpholin-4-yl- quinazolin-4-yl)- phenyl]thiazol-2-yl- methanol1H NMR (500 MHz, DMSO-d6) ppm = 9.11 (s,1H), 7.75 (d, J = 3.2, 1H), 7.72-7.66 (m, 2H),7.61-7.57 (m, 1H), 7.56-7.49 (m, 2H), 7.21(d, J = 2.4, 1H), 7.10 (d, J = 4.8, 1H), 6.10 (d,J = 4.8, 1H), 3.81-3.75 (m, 4H), 3.48-3.43 (m,4H) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H18F2N4O2S | ||
| Mol. Mass. | 440.466 | ||
| SMILES | OC(c1nccs1)c1cc(F)c(F)c(c1)-c1ncnc2cc(ccc12)N1CCOCC1 | ||
| Structure | 
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