Reaction Details |
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Target | E3 ubiquitin-protein ligase XIAP [241-356] |
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Ligand | BDBM13212 |
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Substrate/Competitor | Smac-derived peptide |
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Meas. Tech. | Fluorescence Polarization Competitive Binding Assay |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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Ki | 61±6 nM |
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Citation | Sun, H; Nikolovska-Coleska, Z; Lu, J; Qiu, S; Yang, CY; Gao, W; Meagher, J; Stuckey, J; Wang, S Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic. J Med Chem49:7916-20 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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E3 ubiquitin-protein ligase XIAP [241-356] |
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Name: | E3 ubiquitin-protein ligase XIAP [241-356] |
Synonyms: | API3 | BIR3 domain of X-linked inhibitor of apoptosis protein | BIRC4 | E3 ubiquitin-protein ligase (XIAP-BIR3) | E3 ubiquitin-protein ligase XIAP BIR-3 | E3 ubiquitin-protein ligase XIAP BIR3 | IAP3 | X chromosome-linked inhibitor of apoptosis BIR3 domain (XIAP BIR3) | X-linked inhibitor of apoptosis protein BIR3 domain (XIAP BIR-3) | XIAP | XIAP-BIR3 | XIAP_HUMAN | baculovirus IAP repeat 3 (BIR3) domain of XIAP |
Type: | Protein Binding Domain |
Mol. Mass.: | 13276.62 |
Organism: | Homo sapiens (Human) |
Description: | BIR3 of XIAP: RESIDUES 241-356. |
Residue: | 116 |
Sequence: | SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
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BDBM13212 |
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Smac-derived peptide |
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Name: | Smac-derived peptide |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 619.76 |
Organism: | n/a |
Description: | 5-carboxyfluorescein was coupled to
the lysine side chain of the mutated Smac peptide. |
Residue: | 5 |
Sequence: | |