| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM335742 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Inhibitory Assay |
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| IC50 | 29900±n/a nM |
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| Citation |  Edwards, HJ; Evans, DM; Davie, RL; Rooker, DP; Hewison, SJ Bicyclic inhibitors US Patent US9738641 Publication Date 8/22/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM335742 |
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| n/a |
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| Name | BDBM335742 |
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| Synonyms: | 1-{4-[4-(4-Aminomethyl-benzylamino)-pyrrolo[3,2-c]pyridin-1-ylmethyl]-benzyl}-1H-pyridin-2-one | US9738641, 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27N5O |
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| Mol. Mass. | 449.5469 |
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| SMILES | NCc1ccc(CNc2nccc3n(Cc4ccc(Cn5ccccc5=O)cc4)ccc23)cc1 |
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| Structure | 
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