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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Coagulation factor VII | ||
| Ligand | BDBM13563 | ||
| Substrate/Competitor | BDBM13553 | ||
| Meas. Tech. | Serine Protease Inhibition Assay | ||
| pH | 7.8±n/a | ||
| Temperature | 295.15±n/a K | ||
| Ki | 110±n/a nM | ||
| Citation |  Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett15:5344-52 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Coagulation factor VII | |||
| Name: | Coagulation factor VII | ||
| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 51599.89 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 466 | ||
| Sequence: |
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| BDBM13563 | |||
| BDBM13553 | |||
| Name | BDBM13563 | ||
| Synonyms: | 2-[(4-carbamimidoylphenyl)amino]-2-{3-ethoxy-5-[(4-hydroxycyclohexyl)oxy]phenyl}acetic acid | phenylglycine deriv. 11 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H29N3O5 | ||
| Mol. Mass. | 427.4935 | ||
| SMILES | CCOc1cc(O[C@H]2CC[C@H](O)CC2)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O |r,wU:7.6,wD:10.10,(-7.94,9.1,;-6.61,8.33,;-5.27,9.1,;-3.94,8.33,;-2.61,9.1,;-1.27,8.33,;.06,9.1,;1.39,8.33,;2.73,9.1,;4.06,8.33,;4.06,6.79,;5.4,6.02,;2.73,6.02,;1.39,6.79,;-1.27,6.79,;-2.61,6.02,;-3.94,6.79,;-2.61,4.48,;-1.27,3.71,;-1.27,2.17,;-2.61,1.4,;-2.61,-.14,;-1.27,-.91,;.06,-.14,;.06,1.4,;-1.27,-2.45,;-2.61,-3.22,;.06,-3.22,;-3.94,3.71,;-5.27,4.48,;-3.94,2.17,)| | ||
| Structure | 
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