| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
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| Ligand | BDBM200991 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro AMPK Activation Assay |
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| pH | 7.3±n/a |
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| EC50 | 4286±0 nM |
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| Comments | extracted |
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| Citation |  Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Benzimidazole tetrahydrofuran derivatives US Patent US9540364 Publication Date 1/10/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
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| Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
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| Synonyms: | AAPK1_HUMAN | ACACA kinase | AMP-activated protein kinase alpha-1/beta-2/gamma-2 | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | AMPK1 | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1 |
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| Type: | Protein |
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| Mol. Mass.: | 64023.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13131 |
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| Residue: | 559 |
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| Sequence: | MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG
IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID
DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI
MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE
ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG
SHTIEFFEMCANLIKILAQ
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| BDBM200991 |
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| n/a |
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| Name | BDBM200991 |
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| Synonyms: | US9540364, example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20ClFN2O4 |
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| Mol. Mass. | 454.878 |
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| SMILES | OC[C@H]1OC[C@@H](Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2cccc(F)c2)[C@@H]1O |r| |
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| Structure | 
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