Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 2 |
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Ligand | BDBM13602 |
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Substrate/Competitor | BDBM13594 |
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Meas. Tech. | PTP1B and TCPTP Inhibition Assay |
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pH | 6.3±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 20±n/a nM |
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Citation | Scapin, G; Patel, SB; Becker, JW; Wang, Q; Desponts, C; Waddleton, D; Skorey, K; Cromlish, W; Bayly, C; Therien, M; Gauthier, JY; Li, CS; Lau, CK; Ramachandran, C; Kennedy, BP; Asante-Appiah, E The structural basis for the selectivity of benzotriazole inhibitors of PTP1B. Biochemistry42:11451-9 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 2 |
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Name: | Tyrosine-protein phosphatase non-receptor type 2 |
Synonyms: | PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP) |
Type: | Protein |
Mol. Mass.: | 48481.80 |
Organism: | Homo sapiens (Human) |
Description: | P17706 |
Residue: | 415 |
Sequence: | MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
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BDBM13602 |
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BDBM13594 |
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Name | BDBM13602 |
Synonyms: | 6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro(phosphono)methyl]phenyl}-2-phenylpropyl]phenyl}-2-methylquinoline-8-phosphonic acid | Aryldifluoromethyl-Phosphonic Acid Inhibitor 9 | CHEMBL268526 |
Type | Small organic molecule |
Emp. Form. | C38H32F2N4O6P2 |
Mol. Mass. | 740.6282 |
SMILES | Cc1ccc2cc(cc(c2n1)P(O)(O)=O)-c1ccc(CC(Cc2ccc(cc2)C(F)(F)P(O)(O)=O)(c2ccccc2)n2nnc3ccccc23)cc1 |
Structure |
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