| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM13689 |
|---|
| Substrate/Competitor | BDBM12500 |
|---|
| Meas. Tech. | Factor Xa Inhibition Assay |
|---|
| Ki | 140±n/a nM |
|---|
| Citation |  Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Structural requirements for factor Xa inhibition by 3-oxybenzamides with neutral P1 substituents: combining X-ray crystallography, 3D-QSAR, and tailored scoring functions. J Med Chem48:3290-312 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54726.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
|---|
| BDBM13689 |
|---|
| BDBM12500 |
|---|
| Name | BDBM13689 |
|---|
| Synonyms: | 3-Oxybenzamide 75 | 3-[2-(2,4-dichlorophenyl)ethoxy]-N-[(1-ethanimidoylpiperidin-4-yl)methyl]-4-methylbenzamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H29Cl2N3O2 |
|---|
| Mol. Mass. | 462.412 |
|---|
| SMILES | CC(=N)N1CCC(CNC(=O)c2ccc(C)c(OCCc3ccc(Cl)cc3Cl)c2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
