Reaction Details |
| Report a problem with these data |
Target | Coagulation factor X |
---|
Ligand | BDBM13706 |
---|
Substrate/Competitor | BDBM12500 |
---|
Meas. Tech. | Factor Xa Inhibition Assay |
---|
Ki | 167±n/a nM |
---|
Citation | Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Structural requirements for factor Xa inhibition by 3-oxybenzamides with neutral P1 substituents: combining X-ray crystallography, 3D-QSAR, and tailored scoring functions. J Med Chem48:3290-312 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Coagulation factor X |
---|
Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
BDBM13706 |
---|
BDBM12500 |
---|
Name | BDBM13706 |
Synonyms: | 1-({3-[2-(2,4-dichlorophenyl)ethoxy]-4,5-dimethoxyphenyl}carbonyl)-4-(pyridin-4-ylmethyl)piperazine | 3-Oxybenzamide 92 |
Type | Small organic molecule |
Emp. Form. | C27H29Cl2N3O4 |
Mol. Mass. | 530.443 |
SMILES | COc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1OC)C(=O)N1CCN(Cc2ccncc2)CC1 |
Structure |
|