Ki Summary

Reaction Details

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Target

Flap endonuclease 1

Ligand

BDBM168744

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

1.000±n/a nM

Citation

Bacani, GM; Eccles, W; Fitzgerald, AE; Goldberg, SD; Hack, MD; Hawryluk, NA; Jones, WM; Keith, JM; Krawczuk, P; Lebsack, AD; Lee-Dutra, A; Liu, J; McClure, KJ; Meduna, SP; Pippel, DJ; Rosen, MD; Sales, ZS Flap modulators US Patent US9745328 Publication Date 8/29/2017

More Info.:

Get all data from this article, Assay Method

Flap endonuclease 1

Name:

Flap endonuclease 1

Synonyms:

DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1

Type:

PROTEIN

Mol. Mass.:

42602.57

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1517026

Residue:

380

Sequence:

MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK

BDBM168744

n/a

Name

BDBM168744

Synonyms:

US9079866, 134 | US9745328, Compound 134 | US9884878, Compound 134

Type

Small organic molecule

Emp. Form.

C22H24FN5O2S

Mol. Mass.

441.522

SMILES

N[C@H]1CC[C@H](CC1)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 |r,wU:4.7,1.0,(-6.16,-5.33,;-5.39,-4,;-6.16,-2.67,;-5.39,-1.33,;-3.85,-1.33,;-3.08,-2.67,;-3.85,-4,;-3.08,,;-3.85,1.33,;-5.18,.56,;-2.52,2.1,;-4.62,2.67,;-6.16,2.67,;-6.93,4,;-6.16,5.33,;-4.62,5.33,;-3.85,4,;-2.31,4,;-1.54,5.33,;,5.33,;.77,4,;,2.67,;.77,1.33,;-1.54,2.67,;2.31,4,;3.08,5.33,;4.62,5.33,;5.39,4,;6.93,4,;4.62,2.67,;3.08,2.67,)|

Structure