| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 3-kinase regulatory subunit beta |
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| Ligand | BDBM338879 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 5.5±n/a nM |
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| Citation |  Castro, AC; Evans, CA; Janardanannair, S; Lescarbeau, A; Liu, T; Tremblay, MR Heterocyclic compounds and uses thereof US Patent US9751888 Publication Date 9/5/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 3-kinase regulatory subunit beta |
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| Name: | Phosphatidylinositol 3-kinase regulatory subunit beta |
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| Synonyms: | P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 81542.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00459 |
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| Residue: | 728 |
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| Sequence: | MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA
LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALG
PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP
ALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR
LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE
TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG
PGPPPAAR
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| BDBM338879 |
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| n/a |
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| Name | BDBM338879 |
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| Synonyms: | US9751888, Compound 70 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19ClN6O3 |
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| Mol. Mass. | 474.899 |
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| SMILES | C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(Cl)c2c(=O)n1-c1ccc(O)cc1 |r| |
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| Structure | 
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