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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Phosphatidylinositol 3-kinase regulatory subunit beta | ||
| Ligand | BDBM338893 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 300±n/a nM | ||
| Citation |  Castro, AC; Evans, CA; Janardanannair, S; Lescarbeau, A; Liu, T; Tremblay, MR Heterocyclic compounds and uses thereof US Patent US9751888 Publication Date 9/5/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Phosphatidylinositol 3-kinase regulatory subunit beta | |||
| Name: | Phosphatidylinositol 3-kinase regulatory subunit beta | ||
| Synonyms: | P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 81542.75 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00459 | ||
| Residue: | 728 | ||
| Sequence: |
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| BDBM338893 | |||
| n/a | |||
| Name | BDBM338893 | ||
| Synonyms: | US9751888, Compound 84 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H18ClFN6O2 | ||
| Mol. Mass. | 476.89 | ||
| SMILES | C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1F |r,wD:1.0,(-2,.62,;-.49,.94,;-.02,2.4,;-1.05,3.55,;-2.56,3.23,;-.57,5.01,;-1.48,6.26,;-3.02,6.26,;-.57,7.5,;.89,7.03,;2.23,7.8,;3.56,7.03,;3.56,5.49,;2.23,4.72,;.89,5.49,;.54,-.21,;2.04,.11,;3.07,-1.03,;4.58,-.71,;5.61,-1.85,;5.13,-3.32,;3.63,-3.64,;3.15,-5.1,;2.6,-2.49,;1.09,-2.81,;.61,-4.28,;.06,-1.67,;-1.45,-1.99,;-2.48,-.85,;-3.98,-1.17,;-4.46,-2.63,;-3.43,-3.77,;-1.92,-3.45,;-.89,-4.6,)| | ||
| Structure | 
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