| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
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| Ligand | BDBM14061 |
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| Substrate/Competitor | BDBM13015 |
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| Meas. Tech. | Radiochemical Assay for PNMT Activity |
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| pH | 8±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 260±30 nM |
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| Citation |  McMillan, FM; Archbold, J; McLeish, MJ; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase. J Med Chem47:37-44 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Phenylethanolamine N-methyltransferase |
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| Name: | Phenylethanolamine N-methyltransferase |
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| Synonyms: | Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase |
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| Type: | Enzyme |
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| Mol. Mass.: | 30916.97 |
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| Organism: | Bos taurus (bovine) |
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| Description: | n/a |
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| Residue: | 283 |
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| Sequence: | MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
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| BDBM14061 |
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| BDBM13015 |
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| Name | BDBM14061 |
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| Synonyms: | 8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine | CHEMBL38681 | LY134046 | tetrahydrobenzazepine (THBA) deriv. |
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| Type | Small organic molecule |
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| Emp. Form. | C10H11Cl2N |
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| Mol. Mass. | 216.107 |
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| SMILES | Clc1ccc2CCCNCc2c1Cl |
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| Structure | 
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