Reaction Details |
| Report a problem with these data |
Target | P2X purinoceptor 7 |
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Ligand | BDBM203314 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Ca2+ Flux Assay |
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pH | 7.4±n/a |
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Ki | 4.90±n/a nM |
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IC50 | 31±n/a nM |
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Comments | extracted |
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Citation | Letavic, MA; Rudolph, DA P2X7 modulators US Patent US9540388 Publication Date 1/10/2017 |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 7 |
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Name: | P2X purinoceptor 7 |
Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
Type: | Protein |
Mol. Mass.: | 68602.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99572 |
Residue: | 595 |
Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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BDBM203314 |
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n/a |
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Name | BDBM203314 |
Synonyms: | (6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(5-fluoro-6-methylpyridin-2-yl)-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine | US10053462, 193 | US9540388, 193 |
Type | Small organic molecule |
Emp. Form. | C22H18ClF4N5O |
Mol. Mass. | 479.858 |
SMILES | Cc1nc(ccc1F)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F |r,THB:20:19:11.18.17:15.14.13| |
Structure |
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