| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase Mdm2 [1-188] |
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| Ligand | BDBM339934 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Homogenous Time-Resolved Fluorescence Assay |
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| IC50 | <0.100±n/a nM |
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| Citation |  Gonzalez Buenrostro, A; Li, Y; Medina, JC; Olson, SH Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer US Patent US9758495 Publication Date 9/12/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase Mdm2 [1-188] |
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| Name: | E3 ubiquitin-protein ligase Mdm2 [1-188] |
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| Synonyms: | E3 ubiquitin-protein ligase Mdm2 (aa 1-188) | MDM2 | MDM2_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 21319.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00987[1-188] |
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| Residue: | 188 |
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| Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDS
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| BDBM339934 |
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| n/a |
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| Name | BDBM339934 |
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| Synonyms: | US9758495, 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H35Cl2FN2O6S |
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| Mol. Mass. | 677.61 |
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| SMILES | CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](O[C@](C)(Cc2ccc(cn2)C(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)c(F)c1 |
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| Structure | 
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