| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tryptophan 2,3-dioxygenase |
|---|
| Ligand | BDBM339929 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Activity Assay |
|---|
| IC50 | 560±n/a nM |
|---|
| Citation |  Crosignani, S; Cauwenberghs, S; Driessens, G; Deroose, F 3-(indol-3-yl)-pyridine derivatives, pharmaceutical compositions and methods for use US Patent US9758505 Publication Date 9/12/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tryptophan 2,3-dioxygenase |
|---|
| Name: | Tryptophan 2,3-dioxygenase |
|---|
| Synonyms: | T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47874.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_825691 |
|---|
| Residue: | 406 |
|---|
| Sequence: | MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
|
|
|
|---|
| BDBM339929 |
|---|
| n/a |
|---|
| Name | BDBM339929 |
|---|
| Synonyms: | 6-fluoro-3-(6-(piperidin-4- yloxy)pyridin-3-yl)-1H-indole | US9758505, 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18FN3O |
|---|
| Mol. Mass. | 311.3534 |
|---|
| SMILES | Fc1ccc2c(c[nH]c2c1)-c1ccc(OC2CCNCC2)nc1 |
|---|
| Structure | 
|
|---|
Search and Browse
