| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [1-249,301-1210,T790M,L858R] |
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| Ligand | BDBM285865 |
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| Substrate/Competitor | n/a |
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| IC50 | 5.50±n/a nM |
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| Citation |  Lee, K; Niu, D; Petter, RC; Singh, J Heteroaryl compounds and uses thereof US Patent US9765038 Publication Date 9/19/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [1-249,301-1210,T790M,L858R] |
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| Name: | Epidermal growth factor receptor [1-249,301-1210,T790M,L858R] |
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| Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (T790M/L858R) | HER1 |
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| Type: | Receptor Kinase Domain |
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| Mol. Mass.: | 128584.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[1-249,301-1210,T790M,L858R] |
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| Residue: | 1160 |
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| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLS
INATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAW
PENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLC
YANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVS
RGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPH
CVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGM
VGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKET
EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD
NPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLED
RRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRI
YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKC
WMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDV
VDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYS
SDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHS
TAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGS
TAENAEYLRVAPQSSEFIGA
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| BDBM285865 |
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| n/a |
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| Name | BDBM285865 |
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| Synonyms: | US10081606, Compound I-14 | US9765038, Compound I-14 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20BrN5O3 |
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| Mol. Mass. | 470.319 |
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| SMILES | COc1cccc(Nc2ncc(Br)c(Nc3cccc(NC(=O)C=C)c3)n2)c1OC |
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| Structure | 
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