Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
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Ligand | BDBM14267 |
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Substrate/Competitor | BDBM13466 |
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Meas. Tech. | Enzymatic Assay |
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Temperature | 298.15±n/a K |
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Ki | 140±n/a nM |
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Comments | extracted |
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Citation | Wan, ZK; Lee, J; Xu, W; Erbe, DV; Joseph-McCarthy, D; Follows, BC; Zhang, YL Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48. Bioorg Med Chem Lett16:4941-5 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
Synonyms: | PTN1_HUMAN | PTP-1B | PTP1B | PTPN1 | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase, non-receptor type 1 |
Type: | Enzyme |
Mol. Mass.: | 34670.65 |
Organism: | Homo sapiens (Human) |
Description: | The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli. |
Residue: | 298 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
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BDBM14267 |
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BDBM13466 |
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Name | BDBM14267 |
Synonyms: | 4-bromo-3-(carboxymethoxy)-5-[4-(2-formamidoacetic acid)phenyl]thiophene-2-carboxylic acid | Monocyclic thiophene analog 36 |
Type | Small organic molecule |
Emp. Form. | C16H12BrNO8S |
Mol. Mass. | 458.237 |
SMILES | OC(=O)COc1c(Br)c(sc1C(O)=O)-c1ccc(NC(=O)CC(O)=O)cc1 |
Structure |
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