| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 12 |
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| Ligand | BDBM342108 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition |
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| IC50 | 20.0±n/a nM |
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| Citation |  Fyfe, MC Kinase inhibitors based upon N-alkyl pyrazoles US Patent US9771353 Publication Date 9/26/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 12 |
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| Name: | Mitogen-activated protein kinase 12 |
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| Synonyms: | ERK6 | MAP kinase p38 gamma | MAPK12 | MK12_HUMAN | Mitogen-activated protein kinase 12 (MAPK12 p38 gamma) | Mitogen-activated protein kinase 12 (p38 gamma) | Mitogen-activated protein kinase 12 Gamma | Mitogen-activated protein kinase p38 gamma (p38 MAPKγ) | SAPK3 | p38 delta/gamma |
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| Type: | Protein |
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| Mol. Mass.: | 41938.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53778 |
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| Residue: | 367 |
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| Sequence: | MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR
VSKETPL
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| BDBM342108 |
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| n/a |
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| Name | BDBM342108 |
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| Synonyms: | 3-((4-((4-(3-(3-(tert-Butyl)-1-ethyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-ethynyl-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)benzamide | US9771353, Example 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H46N8O6 |
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| Mol. Mass. | 734.8432 |
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| SMILES | CCn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCOCCOCCOC)C#C)n2)c2ccccc12)C(C)(C)C |
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| Structure | 
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