| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 12 |
|---|
| Ligand | BDBM342110 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Inhibition |
|---|
| IC50 | 9.00±n/a nM |
|---|
| Citation |  Fyfe, MC Kinase inhibitors based upon N-alkyl pyrazoles US Patent US9771353 Publication Date 9/26/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 12 |
|---|
| Name: | Mitogen-activated protein kinase 12 |
|---|
| Synonyms: | ERK6 | MAP kinase p38 gamma | MAPK12 | MK12_HUMAN | Mitogen-activated protein kinase 12 (MAPK12 p38 gamma) | Mitogen-activated protein kinase 12 (p38 gamma) | Mitogen-activated protein kinase 12 Gamma | Mitogen-activated protein kinase p38 gamma (p38 MAPKγ) | SAPK3 | p38 delta/gamma |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 41938.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P53778 |
|---|
| Residue: | 367 |
|---|
| Sequence: | MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR
VSKETPL
|
|
|
|---|
| BDBM342110 |
|---|
| n/a |
|---|
| Name | BDBM342110 |
|---|
| Synonyms: | 3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide | US9771353, Example 10 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C37H39N9O4 |
|---|
| Mol. Mass. | 673.7635 |
|---|
| SMILES | CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(cc(c4)C(=O)NCCN4CCOCC4)C#C)n3)c3ccccc23)n(C)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
