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TargetPhosphodiesterase 4 and 5 (PDE4 and PDE5)
LigandBDBM14375
Substrate/CompetitorBDBM10851
Meas. Tech.PDE Activity Assay
Ki 13.3±n/a nM
Citation Whitehead JWLee GPGharagozloo PHofer PGehrig AWintergerst PSmyth DMcCoull WHachicha MPatel AKyle DJ 8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyladenine: highly potent and selective PDE4 inhibitors. J Med Chem 48:1237-43 (2005) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Phosphodiesterase 4 and 5 (PDE4 and PDE5)
Name:3',5'-cyclic phosphodiesterase
Synonyms:DPDE3 | PDE43 | PDE4D | Phosphodiesterase 4D
Type:Protein
Mol. Mass.:91092.69
Organism:Homo sapiens (Human)
Description:Q08499
Residue:809
Sequence:
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP
PPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRA
MDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF
AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP
MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPL
TVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF
KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVL
LLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMC
DKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAP
DDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPL
DEQVEEEAVGEEEESQPEACVIDDRSPDT
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BDBM14375
BDBM10851
NameBDBM14375
Synonyms:(2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-8-{2-[(3,4-difluorophenyl)methoxy]propan-2-yl}-3H-purin-6-amine | 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3,4-difluoro-benzyloxy)-1-methyl-ethyl]-3Hpurin-6-ylamine Fumarate | V11294 Analogue 5k
TypeSmall organic molecule
Emp. Form.C28H31F2N5O3
Mol. Mass.523.5742
SMILESCOc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(F)c(F)c2)cc1OC1CCCC1
Structure
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