Reaction Details |
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Target | Tyrosine-protein kinase JAK1 [850-1154] |
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Ligand | BDBM348923 |
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Substrate/Competitor | n/a |
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Meas. Tech. | JAK1 Inhibition Assay |
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IC50 | <100±n/a nM |
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Citation | Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent US10206907 Publication Date 2/19/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase JAK1 [850-1154] |
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Name: | Tyrosine-protein kinase JAK1 [850-1154] |
Synonyms: | JAK1 | JAK1 (aa 850-1154) | JAK1A | JAK1B | JAK1_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 34949.64 |
Organism: | Homo sapiens (Human) |
Description: | P23458[850-1154] |
Residue: | 305 |
Sequence: | EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKS
LKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP
KNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIE
TDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFL
KMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGF
EALLK
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BDBM348923 |
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n/a |
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Name | BDBM348923 |
Synonyms: | N-(5-(4-(pyridin-2- ylmethoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide | US10206907, Compound 37 |
Type | Small organic molecule |
Emp. Form. | C22H19N5O2 |
Mol. Mass. | 385.4186 |
SMILES | O=C(Nc1nc2cccc(-c3ccc(OCc4ccccn4)cc3)n2n1)C1CC1 |
Structure |
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