| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [850-1154] |
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| Ligand | BDBM103737 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | JAK1 Inhibition Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent US10206907 Publication Date 2/19/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [850-1154] |
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| Name: | Tyrosine-protein kinase JAK1 [850-1154] |
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| Synonyms: | JAK1 | JAK1 (aa 850-1154) | JAK1A | JAK1B | JAK1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 34949.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23458[850-1154] |
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| Residue: | 305 |
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| Sequence: | EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKS
LKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP
KNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIE
TDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFL
KMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGF
EALLK
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| BDBM103737 |
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| n/a |
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| Name | BDBM103737 |
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| Synonyms: | US10206907, Compound 234 | US11000528, Cpd # 11 | US8563545, 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23F2N5O |
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| Mol. Mass. | 411.4477 |
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| SMILES | FC1(F)CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1 |
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| Structure | 
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