| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [850-1154] |
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| Ligand | BDBM349184 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | JAK1 Inhibition Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent US10206907 Publication Date 2/19/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [850-1154] |
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| Name: | Tyrosine-protein kinase JAK1 [850-1154] |
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| Synonyms: | JAK1 | JAK1 (aa 850-1154) | JAK1A | JAK1B | JAK1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 34949.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23458[850-1154] |
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| Residue: | 305 |
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| Sequence: | EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKS
LKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP
KNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIE
TDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFL
KMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGF
EALLK
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| BDBM349184 |
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| n/a |
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| Name | BDBM349184 |
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| Synonyms: | Cyclopropanecarboxylic acid (5-{4-[2-oxo-2-(4- trifluoromethyl-piperidin-1- yl)-ethyl]-phenyl}- [1,2,4]triazolo[1,5-a]pyridin-2 yl)-amide | US10206907, Compound 319 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24F3N5O2 |
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| Mol. Mass. | 471.4749 |
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| SMILES | FC(F)(F)C1CCN(CC1)C(=O)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 |
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| Structure | 
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