Reaction Details |
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Target | Tyrosine-protein kinase JAK1 [850-1154] |
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Ligand | BDBM349186 |
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Substrate/Competitor | n/a |
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Meas. Tech. | JAK1 Inhibition Assay |
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IC50 | <100±n/a nM |
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Citation | Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent US10206907 Publication Date 2/19/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase JAK1 [850-1154] |
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Name: | Tyrosine-protein kinase JAK1 [850-1154] |
Synonyms: | JAK1 | JAK1 (aa 850-1154) | JAK1A | JAK1B | JAK1_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 34949.64 |
Organism: | Homo sapiens (Human) |
Description: | P23458[850-1154] |
Residue: | 305 |
Sequence: | EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKS
LKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP
KNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIE
TDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFL
KMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGF
EALLK
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BDBM349186 |
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n/a |
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Name | BDBM349186 |
Synonyms: | Cyclopropanecarboxylic acid (5-{4-[2-(3-methoxy-azetidin- 1-yl)-2-oxo-ethyl]-phenyl} - [1,2,4]triazolo[1,5-a]pyridin-2 yl)-amide | US10206907, Compound 321 |
Type | Small organic molecule |
Emp. Form. | C22H23N5O3 |
Mol. Mass. | 405.4497 |
SMILES | COC1CN(C1)C(=O)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 |
Structure |
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