| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [808-1132] |
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| Ligand | BDBM348998 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | JAK2 Inhibition Assay |
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| IC50 | 300±n/a nM |
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| Citation |  Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent US10206907 Publication Date 2/19/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK2 [808-1132] |
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| Name: | Tyrosine-protein kinase JAK2 [808-1132] |
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| Synonyms: | JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132) |
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| Type: | Protein |
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| Mol. Mass.: | 39171.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60674[808-1132] |
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| Residue: | 335 |
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| Sequence: | FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGK
GNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVC
YSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDL
ATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDE
IYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
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| BDBM348998 |
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| n/a |
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| Name | BDBM348998 |
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| Synonyms: | N-(5-(4-(2-(3- fluorophenylamino)-2- oxoethoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide | US10206907, Compound 116 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20FN5O3 |
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| Mol. Mass. | 445.4457 |
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| SMILES | Fc1cccc(NC(=O)COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1 |
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| Structure | 
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