| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [808-1132] |
|---|
| Ligand | BDBM349182 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | JAK2 Inhibition Assay |
|---|
| IC50 | <100±n/a nM |
|---|
| Citation |  Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent US10206907 Publication Date 2/19/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase JAK2 [808-1132] |
|---|
| Name: | Tyrosine-protein kinase JAK2 [808-1132] |
|---|
| Synonyms: | JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 39171.39 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60674[808-1132] |
|---|
| Residue: | 335 |
|---|
| Sequence: | FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGK
GNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVC
YSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDL
ATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDE
IYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
|
|
|
|---|
| BDBM349182 |
|---|
| n/a |
|---|
| Name | BDBM349182 |
|---|
| Synonyms: | Cyclopropanecarboxylic acid (5-{4-[2-(3,3-difluoro- azetidin-1-yl)-2-oxo-ethyl]- phenyl}-[1,2,4]triazolo[1,5- a]pyridin-2-yl)-amide | US10206907, Compound 317 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H19F2N5O2 |
|---|
| Mol. Mass. | 411.4047 |
|---|
| SMILES | FC1(F)CN(C1)C(=O)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 |
|---|
| Structure | 
|
|---|
Search and Browse
