| Reaction Details |
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 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 [871-1187] |
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| Ligand | BDBM348886 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TYK2 Inhibition Assay |
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| IC50 | >1000±n/a nM |
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| Citation |  Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent US10206907 Publication Date 2/19/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Non-receptor tyrosine-protein kinase TYK2 [871-1187] |
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| Name: | Non-receptor tyrosine-protein kinase TYK2 [871-1187] |
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| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 | Non-receptor tyrosine-protein kinase TYK2 (871-1187) | TYK2 | TYK2 (aa 871-1187) | TYK2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 36255.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29597[871-1187] |
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| Residue: | 317 |
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| Sequence: | PHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVK
ALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL
PRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPE
GHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLE
LIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILK
TVHEKYQGQAPSVFSVC
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| BDBM348886 |
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| n/a |
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| Name | BDBM348886 |
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| Synonyms: | N-(5-(4-(4-methylpiperazin-1- yl)phenyl)-[1,2,4]triazolo[1,5- a]pyridin-2- yl)cyclopropanecarboxamide | US10206907, Compound 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N6O |
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| Mol. Mass. | 376.4549 |
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| SMILES | CN1CCN(CC1)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 |
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| Structure | 
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