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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Monocarboxylate transporter 4 | ||
| Ligand | BDBM345287 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Assay 3: MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells | ||
| IC50 | 3.20±n/a nM | ||
| Citation |  Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Monocarboxylate transporter 4 | |||
| Name: | Monocarboxylate transporter 4 | ||
| Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 49474.36 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_104604 | ||
| Residue: | 465 | ||
| Sequence: |
| ||
| BDBM345287 | |||
| n/a | |||
| Name | BDBM345287 | ||
| Synonyms: | 2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclopropylmethoxy)phenyl]pyrazol-3- yl]methoxy]-2-methyl-propanoic acid. 1HNMR (CDCl3): $#948; 0.25-0.29 (m, 2H), 0.58-0.63 (m, 2H), 14.16-1.20 (m, 1H), 1.55 (s, 6H), 5.58 (d, 2H), 4.63 (s, 2H), 5.42 (s, 2H), 6.40 (s, 1H), 6.374-6.78 (m, 2H), 6.84-6.93 (m, 2H), 7.18-7.28 (m, 3H), 7.33-7.35 (m, 1H). | US10202350, Example 33 | US10214492, Example 33 | US11292767, Example 33 | US11724989, Example 33 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H27ClN2O4 | ||
| Mol. Mass. | 454.946 | ||
| SMILES | CC(C)(OCc1cc(-c2cccc(OCC3CC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O | ||
| Structure | 
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