Reaction Details |
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Target | Monocarboxylate transporter 4 |
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Ligand | BDBM345293 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Assay 3: MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells |
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IC50 | 5.40±n/a nM |
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Citation | Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Monocarboxylate transporter 4 |
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Name: | Monocarboxylate transporter 4 |
Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 |
Type: | PROTEIN |
Mol. Mass.: | 49474.36 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_104604 |
Residue: | 465 |
Sequence: | MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
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BDBM345293 |
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n/a |
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Name | BDBM345293 |
Synonyms: | 2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclopropoxy)phenyl]pyrazol-3- yl]methoxy]-2-methyl-propanoic acid. 1HNMR (CDCl3): $#948; 0.55-0.68 (m 4H), 1.55 (s, 6H), 3.50-3.54 (m 1H), 4.63 (s, 2H), 5.44 (s, 2H), 6.42 (s, 1H), 6.76-7.02 (m, 4H), 7.17-7.35 (m, 4H). | US10202350, Example 39 | US10214492, Example 39 | US11292767, Example 39 | US11724989, Example 39 |
Type | Small organic molecule |
Emp. Form. | C24H25ClN2O4 |
Mol. Mass. | 440.919 |
SMILES | CC(C)(OCc1cc(-c2cccc(OC3CC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O |
Structure |
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