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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Monocarboxylate transporter 4 | ||
| Ligand | BDBM345316 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Assay 3: MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells | ||
| IC50 | 33.0±n/a nM | ||
| Citation |  Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Monocarboxylate transporter 4 | |||
| Name: | Monocarboxylate transporter 4 | ||
| Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 49474.36 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_104604 | ||
| Residue: | 465 | ||
| Sequence: |
| ||
| BDBM345316 | |||
| n/a | |||
| Name | BDBM345316 | ||
| Synonyms: | 2-([1-[(3-methoxyphenyl)methyl]-5-[3-(2- methylpropoxy)phenyl]-1H-pyrazol-3- yl]methoxy)-2-methylpropanoic acid LC-MS (ES, m/z): 453 1H-NMR (400 MHz, MeOD) $#948; 0.99 (6 H, d), 1.53 (6 H, s), 1.99 (1 H, dq), 3.55 (2 H, d), 3.73 (3 H, s), 4.59 (2 H, s), 5.33 (2 H, s), 6.50 (1 H, s), 6.56-6.65 (2 H, m), 6.78- 6.86 (2 H, m), 6.92-7.00 (2 H, m), 7.22 (1 H, t), 7.33 (1 H, t). | US10202350, Example 62 | US10214492, Example 62 | US11292767, Example 62 | US11724989, Example 62 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H32N2O5 | ||
| Mol. Mass. | 452.5427 | ||
| SMILES | COc1cccc(Cn2nc(COC(C)(C)C(O)=O)cc2-c2cccc(OCC(C)C)c2)c1 | ||
| Structure | 
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