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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | CREB-binding protein | ||
| Ligand | BDBM349249 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | CBP TR-FRET Binding Assay | ||
| IC50 | 37.0±n/a nM | ||
| Citation |  Romero, FA; Magnuson, SR; Pastor, R; Tsui, VH; Murray, J; Crawford, T; Burdick, DJ; Albrecht, BK; Cote, A; Taylor, AM; Nasveschuck, CG; LeBlanc, Y; Hewitt, MC; Lai, KW; Chen, K Therapeutic compounds and uses thereof US Patent US10206931 Publication Date 2/19/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| CREB-binding protein | |||
| Name: | CREB-binding protein | ||
| Synonyms: | CBP | CBP_HUMAN | CREB-binding protein (CBP) | CREB-binding protein (CREBBP) | CREBBP | ||
| Type: | Transcription Coactivator | ||
| Mol. Mass.: | 265411.66 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q92793 | ||
| Residue: | 2442 | ||
| Sequence: |
| ||
| BDBM349249 | |||
| n/a | |||
| Name | BDBM349249 | ||
| Synonyms: | (4R)-6-(1-tert-butyl-3-methyl-indol-2-yl)-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one | US10206931, Example 56 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H27N3O | ||
| Mol. Mass. | 361.48 | ||
| SMILES | C[C@@H]1CC(=O)Nc2cccc(-c3c(C)c4ccccc4n3C(C)(C)C)c2N1 |r,wU:1.0,(4.32,-.02,;3.55,1.31,;4.21,2.7,;3.55,4.09,;4.32,5.42,;2.04,4.43,;.84,3.47,;-.49,4.24,;-1.83,3.47,;-1.83,1.93,;-.49,1.16,;-.49,-.38,;.75,-1.29,;2.09,-.52,;.28,-2.75,;1.05,-4.09,;.28,-5.42,;-1.26,-5.42,;-2.03,-4.09,;-1.26,-2.75,;-1.74,-1.29,;-3.23,-.89,;-4.32,-1.98,;-2.14,.2,;-3.63,.6,;.84,1.93,;2.04,.97,)| | ||
| Structure | 
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