| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Intermediate conductance calcium-activated potassium channel protein 4 |
|---|
| Ligand | BDBM205077 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 7.3±n/a |
|---|
| IC50 | 64.0±0 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Demnitz, J; Jorgensen, S Tetrazole derivatives and their use as potassium channel modulators US Patent US9556132 Publication Date 1/31/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Intermediate conductance calcium-activated potassium channel protein 4 |
|---|
| Name: | Intermediate conductance calcium-activated potassium channel protein 4 |
|---|
| Synonyms: | IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47723.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1361891 |
|---|
| Residue: | 427 |
|---|
| Sequence: | MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
|
|
|
|---|
| BDBM205077 |
|---|
| n/a |
|---|
| Name | BDBM205077 |
|---|
| Synonyms: | US9556132, 56 | process for preparing 2-{5-[2-(2-methoxyphenyl)phenyl]-1h-1,2,3,4-tetrazol-1-yl}benzonitrile |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H15N5O |
|---|
| Mol. Mass. | 353.3767 |
|---|
| SMILES | COc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1C#N |
|---|
| Structure | 
|
|---|
Search and Browse
