| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 2/3 |
|---|
| Ligand | BDBM320142 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Intracellular Calcium Measurement to Assess Antagonist Activity |
|---|
| IC50 | 70.0±n/a nM |
|---|
| Citation |  Davenport, AJ; Bräuer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J 1,3-thiazol-2-yl substituted benzamides US Patent US10202369 Publication Date 2/12/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 2/3 |
|---|
| Name: | P2X purinoceptor 2/3 |
|---|
| Synonyms: | P2X2/3 | P2X2/P2X3 heterotrimeric receptor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | P2X purinoceptor 2 |
|---|
| Synonyms: | ATP receptor | P2RX2 | P2RX2_HUMAN | P2X2 | Purinergic receptor | PurinergicP2X2/3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 51765.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | PurinergicP2X2/3 0 HUMAN::Q9UBL9 |
|---|
| Residue: | 471 |
|---|
| Sequence: | MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYV
FIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQ
TQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVED
GASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFK
LGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYN
FRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCD
WILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSG
QEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
|
|
|
|---|
| Component 2 |
| Name: | P2X purinoceptor 3 |
|---|
| Synonyms: | ATP receptor | Glucocorticoid receptor | P2RX3 | P2RX3_HUMAN | P2X purinoceptor 3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor | p2x3 + hsa |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 44292.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P56373 |
|---|
| Residue: | 397 |
|---|
| Sequence: | MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS
QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE
VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
|
|
|
|---|
| BDBM320142 |
|---|
| n/a |
|---|
| Name | BDBM320142 |
|---|
| Synonyms: | 3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide | US10174016, Example 309 | US10202369, Example 309 | US10472354, Example 309 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H29F2N5O2S |
|---|
| Mol. Mass. | 501.592 |
|---|
| SMILES | C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
